Ways (7).whereas necrotic cells can release pIL-1, resulting in myeloid cell chemotaxis and inflammation.142 In fact, the IL-1 proform is known to bind to IL-1R1 and to induce inflammation. To date, however, it is not entirely clear which of the two forms is the most relevant following cell damage. Notably, IL-1 release by stressed endothelial cells was also proposed to be mediated by the formatio
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