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This study, unsaturated fatty acids were shown to act on the mitochondrial respiratory chain and induce its uncoupling, thereby promoting calcium fluxes and subsequent calpaindependent IL-1 release. Moreover, by inducing mitochondrial uncoupling, oleic acid not only promoted IL-1 secretion but was also shown to inhibit IL-1 release. Hence, unsaturated fatty acids accumulating in atherosclerotic pl
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