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Is inhibited by the cytosolic expression of IL-1 receptor-2 (IL-1R2) that binds to pIL-1 and thereby prevents its interaction with calpain and its subsequent secretion (4). However, active caspase-1 cleaves IL-1R2 and thereby enables pIL-1 processing. pIL-1 can also be passively released from damaged cells and, similar to mature IL-1, interacts with IL-1 receptor-1 (IL-1R1) (5). In addition to bei

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